Vitamin Information Center

A diet lacking in B vitamins may result in cognitive problems, new findings suggest.

Vitamin B deficiency could result in cognitive impairment, according to new research published in Proceedings of the National Academy of Sciences.

Researchers from the Jean Mayer USDA Human Nutrition Research Centre on Ageing (HNRCA) at Tufts University found that mice given a diet which was deficient in three B-vitamins showed cognitive dysfunction as well as reductions in both brain capillary length and density.

The mice deficient in B-vitamins took longer to perform tasks such as navigating a water maze.

Dr Aron Troen, lead author of the study and assistant professor at Tufts University’s Friedman School of Nutrition Science and Policy, commented: “Mice fed a diet deficient in folate and vitamins B12 and B6 demonstrated significant deficits in spatial learning and memory compared with normal mice.”

Meanwhile, a separate study has suggested that regular walking could have a positive effect for people with memory problems.

A study published in the Journal of the American Medical Association suggested that individuals aged over 50 who go walking for over two-and-a-half hours a week can see significant improvements in memory problems

Taking vitamin C or E supplements, either individually or in combination, does not appear to lower the risk of dementia or Alzheimer’s disease in older adults, study findings suggest.”Our study confirms findings from other studies,” lead investigator Dr Shelly L. Gray of the University of Washington, Seattle said. Vitamin E does not prevent memory problems or dementia.

Gray and colleagues followed 2 969 adults, 65 years of age or older, for an average of 5.5 years to determine if the use of vitamin E or C supplements altered the risk of dementia or Alzheimer’s disease.

How the study was done
At study entry, nearly 33 and 38 percent, respectively, reported using vitamin E and C supplements, and 25 percent of the participants reported taking the vitamin supplements concurrently, the researchers reported the Journal of the American Geriatrics Society.

The participants were an average of 75 years old and had no cognitive impairments. The investigators conducted biennial assessments for dementia and Alzheimer’s disease.

Over the course of the study, 405 participants developed dementia and of these, 289 developed Alzheimer’s disease. As mentioned, the researchers observed no relationship between vitamin supplements and dementia risk.

The current evidence does not support the use of vitamin E or C supplements for the prevention of dementia in older adults, Gray and colleagues conclude.

“Older adults are still encouraged to eat a balanced diet with plenty of fruits and vegetables,” Gray said. These foods provide natural sources of vitamins E and C and other substances that may have health benefits. � (ReutersHealth)