Vitamin A

Vitamin A
•Found in animal foods and converted from beta-carotene in plant foods.
•Required for vision, gene expression, reproduction, embryonic development, red
blood cell production, and immune function.
•Prescription vitamin A derivatives are used to treat skin conditions (acne) and reti-
nitis pigmentosa (genetic eye disease).
•Defi ciency is rare in Canada, but common in developing countries due to malnutri-
tion. It causes night blindness, dry eyes and skin, and impaired growth.
•Drugs that deplete vitamin A: cholestyramine, colestipol, mineral oil, and neomycin.
•Supplements should be avoided by those at risk of lung cancer (smokers) or liver
toxicity (alcoholics, liver disease).
•Doses greater than 10,000 IU daily should be avoided by pregnant women due to the
risk of birth defects. Most prenatal vitamins provide 5,000 IU.
•Doses greater than 5,000 IU may increase risk of osteoporosis.
•Supplements of vitamin A beyond what is provided in a multivitamin are not rec-
ommended due to risk of toxicity. To avoid this risk, choose a multivitamin that
contains beta-carotene, which is converted to vitamin A in the liver, but is not as-
sociated with health risks.

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Singing the praises of vitamin C - if used right

“Doctor, should I take vitamin C during the cold and flu season?” If you were to ask 10 doctors this question, you might get 12 different answers.

There is substantial medical research demonstrating that vitamin C is beneficial for viral infections and in preventing pneumonia. At the same time, there is a lot of research suggesting no benefit. These differences may be explained by how much vitamin C per day was used.

Vitamin C is a dietary nutrient that prevents a disease called scurvy. In the 1940s and 1950s, medical research showed high-dose vitamin C to be effective against influenza, leprosy, tuberculosis and even polio. But with the advent of antibiotics, vitamin C therapy was used infrequently and the clinical expertise was gradually lost with each new generation of physicians.

Vitamin C is necessary for a variety of metabolic functions. Besides its role as an antioxidant, it also used in tissue repair, brain chemical production, adrenal function, wound healing, immune function, heart disease, diabetes, lung function, detoxification and cancer prevention.

All animals - except for humans, primates and guinea pigs - make vitamin C. The daily-recommended dose of vitamin C is 500 mg, the minimal amount needed to prevent scurvy. The optimal dose is not known.

However, the average, 40-pound barnyard goat makes 10,000 mg on a daily basis and more than 100,000 mg when stressed. One could postulate that we are under-dosed and that a 170-pound person certainly needs more than 500 mg per day.

So, do we need more than 500 mg of vitamin C during the cold and flu season? The answer is yes. In studies based on 1,000 mg of vitamin C per day, the majority of research indicates fewer and less severe colds. In the research using less than 1,000 mg per day, there doesn’t seem to be any benefit.

What is really interesting is what happens when vitamin C is given intravenously. Vitamin C given intravenously can easily achieve the high blood levels of the goat. In those studies, vitamin C was curative for infectious diseases such as polio.

Intravenous vitamin C also seems to improve healing and stress-related conditions, and some professional and amateur athletes use intravenous vitamin C to minimize fatigue and improve recovery time.

For many of my patients, intravenous vitamin C has proven benefits. High doses of vitamin C orally can cause diarrhea and should not be done in children. Intravenous vitamin C is contraindicated for people with certain enzyme deficiencies and kidney stones and should only be done under the direction of a physician.

• Patrick B. Massey M.D., Ph.D., is medical director for complementary and alternative medicine for Alexian Brothers Hospital Network.

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American Diets May Lack Vitamin D

A friend recently told me about how his uncle had heard that garlic could help lower his high blood pressure. So the uncle generously added garlic salt to his diet.

A little knowledge can kill you.

A similar misunderstanding appears to be spreading about vitamin D. More and more people are realizing that they are lactose intolerant. So they eliminate milk from their diets.

People also are worried about sun exposure and skin cancer, so they slop on sunscreen whenever they go out or otherwise avoid direct sunlight. And mercury is scaring folks away from eating fish.

As a result, some people are losing all sources of vitamin D. For the first time in a century, doctors are seeing a resurgence in rickets, that bone-deforming disease once endemic to wobbly-kneed child laborers in the Victorian era who never saw the light of day.

Pediatricians in Philadelphia have reported more than 150 new cases in the past three years, up from about zero. Washington, D.C., and other areas with large African-American populations are reporting the similar increases.

No formal studies have found the precise cause of the rickets — be it less milk consumption, less sun exposure, or other factors — but it does appear that Americans in general aren’t getting enough vitamin D.

Vitamin Q and A

Vitamin D is a complicated essential micronutrient. The National Institutes of Health convened a panel of experts last September to establish nutritional guidelines. As revealed in the official meeting proceedings, published in the August 2008 issue of the American Journal of Clinical Nutrition, they couldn’t come to any consensus. The published overview is essentially a collective shrug of the shoulders.

Vitamin D is crucial for calcium metabolism — namely, the making of strong bones — and likely for immune function, heart health, cell proliferation and cancer and diabetes protection, at a minimum. An independent study from Johns Hopkins University, published in the current issue of the Archives of Internal Medicine, associated lower levels of vitamin D in the blood with a higher risk of death.

Yet the experts couldn’t agree to any details. The current recommendation is to get 400 IU of vitamin D daily. Many say this isn’t enough, but no one knows how much more is too much.

Complicating issues further is the fact that vitamin D is the only nutrient that can be made entirely in the skin upon exposure to sunlight, yet this varies greatly with skin color and latitude. It’s hard to assess your daily dose. Few foods other than fish contain vitamin D. Milk is fortified with it, but you need four glasses to get 400 IUs.

Out of Africa

Lighter skin is more efficient at producing vitamin D. So African-Americans are at a double disadvantage for synthesizing vitamin D from sunlight — in the United States. Their darker skin blocks the ultraviolet light that triggers this chemical reaction. In their native lands, closer to the equator where sunlight is more direct, their darker skins would have enough sun exposure to synthesize vitamin D.

Peoples in high northern latitudes, such as Europeans, slowly developed lighter skin over tens of thousands of years to adapt to the weaker sunlight to generate enough vitamin D to survive. African-Americans forced migration from Africa occurred over a period of only a few hundred years.

Also, most African Americans — and most of the world, actually — are lactose intolerant and cannot digest cow milk well. So many do not drink enough milk. Natural sources of vitamin D include cod liver oil (as if anyone can stomach this, let alone find it outside their great-grandmother’s cupboard) and salmon and mackerel (tasty, but expensive).

In Philadelphia many rickets cases involve children of Black Muslims, and the culture of conservative clothing likely played a role.

Yet doctors wonder whether the African-American communities are providing a warning call for all of America, as kids of all races drink less milk, the primary albeit artificial source of vitamin D for most clothed, non-farming residents of North America.

Killer rays

More sunlight isn’t the answer. Humans evolved to frolic naked in the sun but also to live about 30 years or so in Africa. Take your fair skin better suited for Scandinavia and place it in Miami for several summers, and you’re going to get skin cancer.

Regardless, for latitudes north of New York City, and considering how people bundle up during winter, there’s not enough sunlight year-round to satisfy the daily vitamin D requirement.

Milk fortification works well. But all vitamin D supplementation and fortification is essentially created equal. Look for new vitamin D recommendations later this year that try to make sense of the ambiguous NIH report.

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Healthy Tip: Vitamins and Minerals

We can get the vitamins and minerals our body needs by eating a balanced, varied and colourful diet.

But there is one vitamin that we can make ourselves, simply by exposing our skin to sunlight.

Vitamin D is made in the skin after interaction with UVB rays and plays a vital role in the build up of bone density.

The importance of vitamin D extends further – it affects immune function, helping to avoid colds and flu and it protects against cancer and the development of diabetes.

A recent study by experts at Harvard Medical School has added to the evidence that a low vitamin D status is linked to an increased risk of heart disease.

Vitamin D may also help regulate blood pressure and be involved in reducing inflammation.

The amount of vitamin D made by our skin depends primarily on the amount of sunlight, which, in turn, depends on:

The latitude we live at – the south has the advantage over the north

The season – summer wins over winter

The time of day – mid-day comes out tops.

Vitamin D production also decreases as we age – it is slower in dark-skinned people and is lower in obese people as vitamin D is thought to be stored in fat, which makes it less readily available.

To ensure our vitamin D levels are kept topped up we need to get out more, whatever the weather as it doesn’t have to be bright sunshine.

By exercising at the same time we will doubly benefit our hearts.

It pays to create opportunities – walk to work, alight from the bus a couple of stops earlier, walk the kids to school, go for a lunchtime walk, get out at the weekend to garden, bike or hike.

Remember not to cover up too much, just leave some skin exposed so that you can actually restore those vitamin D levels.

As springtime sunrays strengthen, 10 to 15 minutes uncovered or with a low sunscreen factor before 11am and after 3pm could be enough to boost our vitamin D status without tanning or burning.

Sunlight is the cheapest way to top up your vitamin D but there are a few foods that contain vitamin D:

Oily fish such as sardines, fresh tuna, salmon, trout, mackerel and kippers – eating two portions of oily fish a week will also provide you with heart-healthy omega 3 fats

Eggs and shiitake mushrooms

Cod liver oil

Fortified breakfast cereals.

For more information and advice about healthy living, contact Heart Research UK on 0113 297 6206 or email lifestyle@heartresearch.org.uk

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Function of Vitamin C

Although vitamin C has long been touted as a preventive measure against the common cold, the available evidence from several large-scale randomized controlled trials does not support this claim. Continue Reading…

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