Vitamin Information Center

Atovaquon + Proguanil (Malarone®)
Definition
Atovaquon interferes with the transport of electrons
inside the plasmodia, proguanil impairs protein
metabolism. The combination of both substances is
effective against all forms of malaria. Treatment is carried
out for three days. As water solubility of atovaquon
is poor, it should be taken with a fatty meal
to improve intestinal resorption. Side effects of the
drugs are headache, cough and gastrointestinal symptoms
(primarily vomiting and diarrhea).

Artemether/Lumefantrine (Riamet®)
Definition
Lumefantrine is derived from the alkaloids of the
bark of the South American cinchona tree (quinine
and quinidine). Its effect results from the impairment
of the metabolic processes in plasmodia. Artemether,
which is extracted from Artemisia annua (Quinghasoso),
impairs parasitic enzymes as well. The substances
are effective against all forms of malaria,
therapy is performed for three days. Side effects are
headache, sleeplessness, dizziness and gastrointestinal
symptoms.

Artemether/Lumefantrine (Riamet®)
Definition
Lumefantrine is derived from the alkaloids of the
bark of the South American cinchona tree (quinine
and quinidine). Its effect results from the impairment
of the metabolic processes in plasmodia. Artemether,
which is extracted from Artemisia annua (Quinghasoso),
impairs parasitic enzymes as well. The substances
are effective against all forms of malaria,
therapy is performed for three days. Side effects are
headache, sleeplessness, dizziness and gastrointestinal
symptoms.