Aminoglycoside Antibiotics

Aminoglycoside Antibiotics
Synonyms
Aminoglycosides
Definition
Aminoglycoside antibiotics are bacteriostatic, that
means they impede the bacteria’s growth. This is
achieved by a change in the permeability of the bacterial
cell wall or disturbances of metabolism. The highest
efficacy is seen for gram-negative germs. In comparison
with other antibiotics, aminoglycosides have only a narrow
therapeutic range. Overdose may result in damage
to hearing, the organ of equilibriumor the kidneys (otoand
nephrotoxic side effects). Nevertheless, especially
in a severe septic course of a disease, aminoglycosides
are indispensable antibiotic therapy. Apart from local
application as salves or drops (which can, for example
be used for infections of the eyes), aminoglycosides can
only be given parenterally.

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