AMERICANS spend more money on vitamin C, roughly $330 million a year, than on any other purportedly immune-boosting supplement, according to the Nutrition Business Journal. Perhaps because it’s been around so long.

“People take vitamin C during cold and flu season because since the 1950s, that’s pretty much what we’ve all been told to do,” said Daniel Fabricant, vice president of scientific and regulatory affairs for the Natural Products Assn., a Washington, D.C.-based trade association. “It’s just in our subconscious mind-set.”

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