The evidence that points unerringly to a link between vitamin D and Scotland’s health statistics can be traced back to a journey undertaken in 1977 by two young Americans, Frank and Cedric Garland, who were studying cancer.
They regularly drove their white Ford Mustang from San Diego, California, to Johns Hopkins Medical School on the east coast, noticing the dramatic change in weather from sunshine to snow. When they saw a map showing that bowel cancer was much more common in the northeast of the United States than it is in the south and west, they immediately understood that sunshine might provide the explanation.
“Everyone else was thinking it must be something that people ate, like the amount of fibre or meat burnt on the barbecue,” said Frank Garland. “We were alert to the difference in climate because we had direct experience of it.”
The Garland brothers went on to show with scientific rigour that bowel cancer is linked to sun exposure. Later they showed that breast and ovarian cancers are also less frequent in sunny regions. At the time, their observations were too simple for doctors and scientists, dazzled by DNA and other modern wonders, to pay much attention. So it was 25 years before their discovery was taken seriously outside a small circle. Now this simple idea is crashing through medical research and bringing a revolution in thinking about the cause of chronic disease.
When bare skin is exposed to the sun it produces vitamin D, which, as doctors have known for many years, is essential for growth of strong bones. But in the past ten years it has become increasingly clear that vitamin D also protects us from a range of chronic diseases, including cancer.
By 2005 the Garlands were able to point to 63 studies that suggested increasing people’s vitamin D levels could reduce the risk of cancer at low cost with few or no adverse effects. According to Bill Grant, a former Nasa scientist turned vitamin D expert, 20,000 cancer deaths a year could be prevented in Britain if we received as much sun as the average American - more if we lived in Florida.
Vitamin D also protects us from heart disease of various kinds, raised blood pressure, stroke and several immune system diseases, including multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis and diabetes. Even sporting fitness and strength may fall off in winter when vitamin D levels are low. Vitamin D is active on almost every tissue of the body, affecting 2,000 different genes.
I have often driven along a route in the Borders that tells a story similar to that of the Garland brothers. The route goes westward from Durham over the Cheviots and the Border hills to Carlisle and Glasgow. Durham, lying as it does on the east coast, is a small enclave of relatively sunny territory, but as we go west and north into Scotland we often encounter dull skies. The majority of Scotland’s population live in an open lowland corridor where the prevailing westerly wind blows cloud and rain in from the Atlantic, too often blocking out the sun. As a result Glasgow and its environs get about 50 per cent less sun than Durham. In fact, Glasgow gets little more sunshine than regions in the far north beyond the Arctic Circle.
This is an invaluable pointer to the health problems of the Scots. For years, experts have tried to explain why people living on Clydeside have recovered less well from economic deprivation than those on Teesside or Wearside in County Durham, whose lives are otherwise not so different. Poor diet, alcohol, drugs and smoking have all been blamed. But the missing ingredient is vitamin D. A baby born in Scotland starts with a health disadvantage, because vitamin D is vital for growth and development from the womb onwards.
Those babies born in March or April, at the end of the winter when vitamin D levels are lowest, are more likely to suffer later on from juvenile diabetes or multiple sclerosis than babies born at other times. Scotland also has the highest incidence of multiple sclerosis in the world, costing many millions of pounds per year as well as causing misery and suffering.
The problem is too urgent for Scotland to leave to Westminster, which has been presented with the evidence, but has failed to grapple with it. A learned committee known as SACN has already reviewed the evidence without taking action. The official advice to mothers in the UK remains that their babies do not need vitamin D until they are six months old. No explanation has ever been given why this should be so.
Yet evidence from abroad suggests that this approach is wrong. In France, scientists have coined the phrase “the French paradox” to explain why the average life-span is so much longer than that in England. Credit has been given to the Mediterranean diet, but in the end exposure to longer hours of sunlight probably has been more important, because of the vitamin D
it supplies. French doctors, recognising its importance, give pregnant women mega-doses of 100,000 units of vitamin D. In Canada, the national Cancer Society recommends that Canadians take at least 1,000 units of vitamin D per day in winter for cancer prevention, and the same in summer if they get little exposure to sunlight. In Canada, mothers living at high latitudes, equivalent to those in Scotland, are told to take 2,000 units of vitamin D per day, which is enough not only to improve their health, but also to put a nourishing amount into their milk.
With the British Government apparently unwilling to go down this route, Scotland, with a far worse health problem, faces a challenge - but also an opportunity. Recognising the weight of evidence now available on vitamin D, it could act fast to improve the nation’s health by convening a committee of experts with a brief to revise government advice to the public.
It could study the French or Canadian models, and adapt their programmes to Scottish needs. It could cut through the tangle of controversy over the health of sunbathing and tanning salons that are also useful sources of vitamin D. It could recommend the development of foods such as bread, orange juice, milk and cooking oil fortified with vitamin D.
The overall cost would not be great. The Scottish government has the power to provide fast-track licences for vitamin D prescription products from EU countries at minimal cost. Vitamin D itself need cost little more than £10 per person per year. The benefit for Scotland would be to tackle a set of health statistics that not only cost the nation millions of pounds every year, but are a stain on its reputation throughout the civilised world.
Oliver Gillie is a scientist and medical journalist. His new book: Scotland’s Health Deficit: An Explanation and a Plan is published today and is available from www.healthresearchforum.org.uk.
Chronc disease linked to vitiamin D deficiency
Cardiovascular Disease
Insufficient vitamin D is known to be a risk factor in heart disease, strokes and high blood pressure. Only the Finns suffer more cardiovascular illness than the Scots, and Scots’ women have had the highest morality rates for heart disease in Europe since the 1950s.
Raised blood pressure is associated with low sun exposure and insufficient vitamin D. Men with low levels of vitamin D are six times more likely to have raised blood pressure than those with high levels. Women with low vitamin D are 2.67 times more likely to have raised blood pressure. Research has shown blood pressure can be lowered by exposing the body to UV or by taking a Vitamin D supplement. A Finnish study shows people with low Vitamin D are at increased risk of having a stroke.
Cancer
People living in higher latitudes are at increased risk of cancer. Experts agree that the cancer risk is likely to be reduced by increasing the average individual’s exposure to the sun and/or by taking a vitamin D supplement of 1,000 units or more per day. In one study there was a 77per cent reduction in cancer in women in their 60s who took this supplement for four years. In another study, women with the lowest vitamin D were found to have a risk of breast cancer five times higher than women with the highest vitamin D levels. One scientist, William Grant, estimates that 17 cancer types are sensitive to UV light and that cancer deaths could be reduced by 14-19 per cent in the UK if everyone took daily vitamin D supplements.
Multiple Sclerosis
Vitamin D modulates the immune system. MS is more prevalent in Scotland than anywhere else in the world: the figure in England and Wales is typically half that of some parts of Scotland. Evidence linking the disease to lack of sunlight has grown. In Tasmania, a cloudier, temperate region of Australia, it is six times more prevalent than in tropical Queensland. In Canada, three times more women now get MS than men.
Diabetes
While obesity appears to be the prime factor in the growth in juvenile diabetes in Scotland, lack of vitamin D is also implicated. Scotland’s incidence of diabetes is surpassed only by Finland, Sweden and Sardinia. Figures for children in Scotland under 15 show the incidence of the disease at almost double that in England. Studies have shown vitamin D supplements given to children can protect against diabetes. The onset of diabetes follows a seasonal pattern - with the fewest new cases in the summer months - in Scotland, North America, Europe and the Southern Hemisphere. Dr Gillie suggests all pregnant and nursing mothers should receive 2,000 to 4,000 units of vitamin D a day. All Infants and children should take a vitamin supplement.
Rheumatoid Arthritis
Low vitamin D levels have been observed in patients and the prevalence of rheumatoid arthritis in Scotland seems to be the highest anywhere. A low prevalence is found in sunny countries. The disease is twice as common in Pakistani women living in England than those living in Pakistan where the sun is much stronger.
Osteomalacia
Insufficient vitamin D may also cause muscle weakness, pains and body sway. Dark skinned people are particularly vulnerable to such aches. An Edinburgh GP tested 99 of her patients aged 15 to 85, many of whom complained of vague musculo-skeletal symptoms or were housebound. About half were Asian. Only 2 per cent had a satisfactory vitamin D level and almost half were deficient.
Inflammatory bowel disease
Low levels of vitamin D together with weak bones are associated with Crohn’s disease. Scotland is more affected by this disease than almost any country in the world. Only Denmark has more deaths. In Aberdeen, since the late 1950s, the incidence has increased five fold, perhaps reflecting a move away from a traditional fish-rich diet.
Colds and Flu
The sunshine vitamin has a dramatic effect on the immune system that enables it to fight infection. Infections occur most during winter, when vitamin D levels are lowest. Evidence suggests severe colds and flu might be much reduced if Vitamin D was taken by the public.
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