Anxiety Disorders

Anxiety Disorders
MICHAEL LINGEN
University of Göttingen, Göttingen, Germany
mlingen@gwdg.de
Synonyms
Panic disorder; Agoraphobia; Social phobia; Specific
phobia; Simple phobia; General anxiety disorder
(GAD); Obsessive-compulsive disorder (OCD); Acute
and post-traumatic stress disorder (PTSD); Hypochondria;
Health anxiety; Health phobia
Definition
Fear and anxiety are not primarily pathological, but
ubiquitous phenomena necessary for life and survival.
It is only in its extreme form that anxiety becomes
problematic. Anxiety is a feeling of apprehension
and fear characterized by physical symptoms such as
palpitations, sweating, and feelings of stress. Anxiety
disorders are a cover term for a variety of mental
disorders in which severe anxiety is a salient symptom.
Unlike the relatively mild, brief anxiety caused
by a stressful event such as an exam or a business presentation,
anxiety disorders are chronic, or can become
chronic, or grow progressively worse if not treated, and
are pathologically associated with other mental disorders.
Basic Characteristics
Epidemiology
Anxiety disorders rank among the most frequent psychological
diseases. 1–2% of the total population are
affected by an anxiety disorder in need of treatment.
Epidemiological studies concluded that the lifetime
prevalence of anxiety disorders is 14% (Regier 1998).
The 12-month prevalence of anxiety disorders is 12.0%,
 specific phobias are most frequent (7.8%), followed
by  panic disorders (12-month prevalence: 2.3%;
Wittchen and Jacobi 2005). The lifetime prevalence of
panic disorders is estimated to be 3–5 percent (Faravelli
et al. 2005). General anxiety disorder (GAD)
shows a lifetime prevalence of 5% in adults (Ballenger
et al. 2001). Prevalence rates of GAD are highest in
middle-aged women (> 45 years).
Aetiology
In a general model, anxieties can be explained as a consequence
of a dysfunctional interpretation of events,
which go hand in hand with a behavior that more
and more strengthens the dysfunction (e. g. avoidance).
According to this model, the ill-making interpretations
are the result of individual, relatively stable convictions
and doctrines. These are triggered by specific situations,
physical reactions or thoughts that influence the
(consequently very selective) processing and interpretation
of information. Most patients, for example, over
estimate dangers and underestimate their own capacity
to deal with them. As soon as a perceived danger
is assessed, a number of negative, automatic thoughts
build up (e. g. self-doubt, sceptic predictions). This process
of building up can be described as a vicious circle:
signs of an assumed dysfunction enhance the perception
of violability and influence the situational cognitions
and the dysfunctional attempts to cope with it;
these consist mainly in avoidance and safety-seeking
behavior. Consequently, the person is convinced that
only this behavior will avert the dreaded catastrophe.
Experiencing that the catastrophe did not occur or perceiving
that the situation could only be managed with
this behavior, suppresses the development of functional
assessments and behaviors. The term “safety-seeking
behaviors” (Salkowskisk 1991) refers to every behavior
used to avoid the dreaded event (e. g. diction or voice
modulation of socially insecure people, always carrying
a mobile phone or medication by people with panic disorders).
Cognitive-behavioral therapy therefore stresses
the need to modify this safety-seeking behavior;
the behavioral-therapeutic approach also distinguishes
between risk-factors (genetic precondition, life story),
triggering or releasing factors (stages or events of life
that were particularly stressful) and maintaining conditions
(e. g. self-energizing processes based on self-evaluation
and assessment of events as catastrophic, leading
to avoidance).
From a psycho-dynamic point of view, in contrast,
the symptoms of anxiety are seen as a result of inner
conflicts or of deficits of the so-called self-structure,
depending on the underlying concept. According to the
conflict model, the psychological defense of unacceptable
emotions (e. g. aggressive or egoistic impulses)
leads to a massive inner conflict which in turn “is frightening”
in the original sense. According to this model,
people would rather suffer from anxiety than have
a conflict with their consciences, an external authority
or other images of themselves; they, however, are not
aware of this inner conflict. The deficit model, on the
other hand, assumes that the anxiety cannot be fought
efficiently because of a weak ego, which then leads to
increasingly strong appearances of anxiety in the form
of symptoms. The continuous failure of psychological
defenses in the face of increasingly trivial stimuli therefore
leads to frequent and massive bouts of anxiety.
Consequences
In most anxiety disorders spontaneous remission is very
rare. On the contrary, these disorders tend to become
chronic at an early stage and sufferers have a high probability
of developing a second anxiety disorder (up to
50%) or a depression (up to 50%). A common combination
is anxiety disorder and substance abuse (up to
40%); this, however, in most cases, has to be regarded
as an unsuccessful attempt by sufferers to treat their
anxiety themselves. It is quite common that an anxiety
disorder finds its expression in somatic symptoms
(e. g. stomach ache) which are mistaken for symptoms
of a physical disease and consequently wrongly
treated. This in turn can lead to feelings of insecurity
in the patient and in extreme cases result in a kind
of vicious circle of increasing anxiety and increasing
somatic symptoms.
Treatment
Until a few years ago, anxiety disorders had been
regarded as difficult to treat. In recent years, however,
newer and more effective therapeutic strategies have
been developed. For all forms of anxiety disorders, psychotherapy
is the method of choice. The benefit or lack
of an additional treatment with medication is still under
debate. The benefit of a pharmaco-therapy as an interim
solution before the onset of psychotherapeutic measures
is undisputed. A permanent therapy with medication
(e. g. antidepressants, benzodiazepines), however,
is not always appropriate, as it prevents the establishment
of functional interpretations and coping strategies
and is also probably not quite harmless because of
potential addictions (as in the case of benzodiazepines).
The general objective of psychotherapy for anxiety disorders
is an adequate reduction of symptoms, a general psychological and physical improvement and, at the
same time, an increase in the quality of life.
Behavioral-therapeutic measures for the treatment of
anxiety disorders are based on the realization that anxieties
aremainly influenced by learning processes,maintaining
conditions (e. g. morbid gain in the form of
social care) and distorted interpretations. Consequently,
the specific therapeutic approach focuses on changing
these conditions, e. g. confrontation with anxietyeliciting
stimulus, relaxation techniques, etc.
A decisive focus in which the psychoanalytical therapy
differs from cognitive-behavioral approaches is the
psychoanalytical handling of the therapeutic relationship
with its specific interactions that are governed by
the patient’s unconscious conflicts. The objective is
that these unconscious conflicts, which are inextricably
linked to previous relationships, can be experienced and
dealt with in the present relationship with the analyst.
Cross-References
 Acute and Post-Traumatic Stress Disorder (PTSD)
 Agoraphobia
 Dissociation
 General Anxiety Disorder (GAD)
 Hypochondria
 Obsessive-Compulsive Disorder (OCD)
 Panic Disorder
 Social Phobia
 Specific Phobia
References
Ballenger JC, Davidson JRT, Lecrubier Y, Nutt DJ, Lydiart RD,
Mayer EA, International Consensus Group on Depression
and Anxiety (2001) Consensus statement on depression, anxiety,
and functional gastrointestinal disorders. J Clin Psychiatr
62:53–58
Barlow DH (2002) Anxiety and its disorders: The nature and
treatment of anxiety and panic, 2nd edn. Guilford, New York
Brunello N, Davidson JR, Deahl M, Kessler RC, Mendlewicz J,
Racagni G, Shalev AY, Zohar J (2001) Posttraumatic stress
disorder: Diagnosis and epidemiology, comorbidity and
social consequences, biology and treatment. Neuropsychobiology
43:150–162
Davey GCL (ed) (1997) Phobias: A handbook of theory, research
and treatment. Wiley, Chichester
Goodman WK, Rudorfer M, Maser JD (2000) Obsessive-compulsive
disorder. Contemporary issues in treatment. Erlbaum,
Mahwah
Goodwin RD, Faravelli C, Rosi C, Cosci F, Truglia E, De
Graaf R, Wittchen HU (2005) The epidemiology of panic
disorder and agoraphobia in Europe. Eur Neuropsychopharmacol
15:435–43
Wittchen HU, Jacobi F (2005) Size and burden of mental disorders
in Europe: A critical review and appraisal for studies.
Eur Neuropsychopharmacol 15:357–76

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Assisted Living Facilities

Assisted Living Facilities
Synonyms
Residential care facility; Personal care home; Domiciliary
care facility; Adult foster care; Adult family homes
Definition
Assisted living facilities offer private rooms or apartments
to people who are not able to live on their own but
are still independent enough that they do not yet need
the continuous care of a  nursing home. The facilities
offer meals, housekeeping assistance, assistance with
 activities of daily living, assistance with medication
administration, social activities, and 24-hour support by
trained staff. Usually, assisted living facilities have the
mission of offering personal autonomy, independence,
and privacy to often frail elderly people in order to provide
homelike settings for them. Facilities that were
built in the recent past are more likely to cater for the
specific requirements of disabled people.

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Assessment of Workplace Hazards

Assessment of Workplace Hazards
Synonyms
Workplace hazards measurements
Definition
Assessing health hazards involves the measurement of
the concentration of potentially hazardous agents in the
workplace to evaluate whether or not there is a risk of
exposure ( workplace hazards).
Once a potential hazard has been recognized in the
workplace, the next step is to assess it to determine if
it is possible for a worker to be exposed and/or determine
if exposure is at a harmful level. The exposure of
workers to the agent must be evaluated to see if there is
a risk of injury to their health. If so, a control will be
needed.
Exposuremeans being in contact or exposed to a potentially
hazardous agent for a determined period of time.
Some agents can cause health effects even though the
period of exposure is very short. Others are harmful
only if exposure is for a prolonged or excessive period
of time. In both cases, the higher the exposure level,
the greater the potential for harm.

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Assessment of Work Ability

Assessment of Work Ability
Synonyms
Fitness for work assessment
Definition
Assessment of work ability is an objective assessment
of the health of employees in relation to their specific
jobs, in order to ensure they can do the job and will
not be a hazard to themselves or others. The assessment
should always be conducted with reference to the
specific job the worker holds or intends to hold. The
reasons for assessment of work ability are numerous,
such as the application or consideration for entry into
employment and assignment to a specific job, the need
to avoid diseases becoming chronic, return to work after
sick leave, or assessment for social benefits.
Assessment of work ability must be specifically jobrelated,
with judgments of fitness being based on the
principle that the employees’ state of health in relation
to their individual jobs will not be hazardous to
themselves or others. It is preferable that these activities
should be undertaken by individuals who are specially
trained or well experienced in occupational medicine.
Assessment of work ability, according to the definition
of work ability, usually involves the measurement
of activities related to personal care, mobility, sensory
perception, communication, recreation, socializing,
and intimacy. It is also related to mental and intellectual
status, psychological distress, individual work environment,
various occupational requirements, and even personal
demographic characteristics. Assessment of work
ability is a difficult task and probably cannot be performed
by a single individual. Available methods that
measure certain dimensions of work ability, such as
functional capacity, physical performance components,
or physical work performance, are generally considered to be hardly sufficient measurements of the real work
ability.
Occupational health service personne are in an excellent
position to make an assessment of work ability as
they have access to both medical and workplace data.
The work ability index (WAI), developed by the Finnish
Institute of Occupational Health, is an instrument, with
high validity, which can provide an integrated number
useful for comparative longitudinal study and followup.

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Ascariasis

Ascariasis
Synonyms
Ascaridosis; Roundworm infection
Definition
Roundworms are spread worldwide; in Africa more
than 90% of the population is infected.Worm eggs can
survive in the soil and stay contagious for a long time
(up to years). People are infected by ingestion of contaminated
foodstuff (containing worm eggs). A transmission
by flies is also possible. In the intestines the
eggs free their larvae. The larvae penetrate the intestinal
wall, reach the liver via the portal vein and then get
into the pulmonary circulation. Penetrating the alveolar
wall, the larvae reach the bronchial system, the windpipe
and then the pharynx. Here they are swallowed
again and reach the intestines where they develop into
adult worms. The females are 30–40cm long, the males
12–30cm. Shedding the eggs with the stool closes the
developmental cycle. The larvae can cause inflammatory
reactions in the various organs, moreover, ascariasis
is responsible for general symptoms like a lack of
appetite, stomach pain and nausea. In severe cases an
ileus can develop, or worms can be vomited. The infection
can be diagnosed by detection of worm eggs in
the stool, or when worms are expelled with the feces.
Ascariasis can be cured by pyrantel, mebendazole or
albendazole.

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Artificial Neural Network

Artificial Neural Network
Synonyms
Neural network
Definition
An analytic modeling technique modeled after the
(hypothesized) processes of learning in the cognitive
system and the neurological functions of the brain.
It is capable of predicting new observations (on specific
variables) from other observations (on the same
or other variables) after executing a process of socalled
learning from existing data. Artificial neural networks
(ANN) are nonlinear and capable of modeling
extremely complex functions by creating connections
between processing elements – the computer equivalent
of neurons. For example, the onset of a particular
medical condition could be associated with a very
complex (e. g., nonlinear and interactive) combination
of changes on a subset of the variables being monitored
(e. g., a combination of heart rate, levels of various
substances in the blood, respiration rate). Neural
networks have been used to recognize this predictive
pattern so that the appropriate treatment can be prescribed.
A distinction can be made between two different
types of ANN– networks designed for supervised
learning tasks (e. g., Multilayer Perceptron, Bayesian
networks, Genetic algorithms) and networks primarily
designed for unsupervised learning (Self Organizing
Feature Map (SOFM, or Kohonen) networks).

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Arthritis

Arthritis
Definition
Arthritis is a group of chronic conditions characterized
by joint inflammation. It is one of the leading causes
of disability in people older than 55 years. There
are more than 100 types of arthritis, with osteoarthritis
and rheumatoid arthritis among the most prominent.
Although the various forms of arthritis are quite different
from each other, they produce common symptoms
which include sore, stiff, inflamed, and painful joints.
There are different causes for arthritis; for some types
theses are not even fully explored. Rheumatoid arthritis
is an autoimmune disorder in which the immune system
begins to act abnormally. Osteoarthritis occurs following
trauma or infection of the joint, or as a result of
aging. Usually, the first line of treatment is medication
to reduce inflammation, swelling, and pain. The medication
is often supported by physical therapy that might
reduce the rate of deterioration of the joints. Surgery is
only applied for the most severe cases.

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Artemether/Lumefantrine (Riamet®)

Artemether/Lumefantrine (Riamet®)
Definition
Lumefantrine is derived from the alkaloids of the
bark of the South American cinchona tree (quinine
and quinidine). Its effect results from the impairment
of the metabolic processes in plasmodia. Artemether,
which is extracted from Artemisia annua (Quinghasoso),
impairs parasitic enzymes as well. The substances
are effective against all forms of malaria,
therapy is performed for three days. Side effects are
headache, sleeplessness, dizziness and gastrointestinal
symptoms.

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Antiseptic

Antiseptic
Synonyms
Antisepsis; Disinfectant; Disinfection of surfaces
Definition
Word-for-word translated from Greek an antiseptic is
a substance used against putrefaction. Disinfectants
reduce the amount of germs on surfaces. Antisepsis
involves the disinfection of areas, materials and objects
as well as disinfection of skin and wounds.

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Antioxidants

Antioxidants
Definition
There are natural antioxidants like vitamin C, vitamin
E, carotinoids and artificial citrates. They are used
in food, pharmaceuticals and in synthetic materials to
avoid the oxidation (reaction with aerial oxygen or other
oxidize chemicals) of sensitive molecules. Mostly
they act as scavengers. Because natural antioxidants
delay or advert the growth and development of many
cells they possibly block the development of cancer.
A lot of antioxidantswhich decrease the hazards of cancer
are found in fruit and vegetables. And they also
make aggressive oxygen particles harmless. It is supposed
that a high intake of fresh fruit and vegetables
has a protective effect against the development e. g. of
cancer.

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